Additional information
| Weight | 1mg |
|---|
Home / IGF-1 LR3
$89.99
Analytical reports
Batch 1358 – IGF-LR3 99.75% 1.22mg
Batch 1665 – IGF-LR3 99.64% 1.09mg
Compound background
IGF-1 LR3 is a 83-amino-acid analog of insulin-like growth factor 1 engineered by (1) extending the native 70-residue sequence with a 13-residue N-terminal peptide and (2) replacing the third amino acid with arginine. These changes reduce its affinity for IGF-binding proteins and protect it from rapid enzymatic cleavage, prolonging plasma half-life from ~10 min to 6–10 h. Freed from most carrier constraints, IGF-1 LR3 more readily engages IGF-1 receptors (and, to a lesser extent, insulin receptors), triggering the canonical PI3K-Akt-mTOR and MAPK/ERK pathways that drive glucose uptake, protein synthesis, mitosis, and tissue remodeling.
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